Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype.

Mechanisms of ageing and development - 1 Mar 2021

Engler Melanie, Fidan Miray, Nandi Sayantan, Cirstea Ion Cristian

Abstract excerpt

Senescence is a biological process that induces a permanent cell cycle arrest and a specific gene expression program in response to various stressors. Following studies over the last few decades, the concept of senescence has evolved from an antiproliferative mechanism in cancer (oncogene-induced senescence) to a critical component of physiological processes associated with embryonic development, tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging, Premature
Share to Cellular Senescence
Share to Costello Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ectodermal Dysplasia

Share to Facies

Share to Failure to Thrive

Share to Heart Defects, Congenital

Share to Noonan Syndrome

Source

Identifiers

PMID: 33309600
DOI: 10.1016/j.mad.2020.111411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype.PMID 33309600Read ↗

Hallmarks of cellular senescence: biology, mechanisms, regulationsSemantic proximity Read ↗

Cellular Senescence: Aging, Cancer, and InjurySemantic proximity Read ↗

Cellular Senescence: Mechanisms and Therapeutic PotentialSemantic proximity Read ↗

Cellular senescence in development, regeneration and diseaseSemantic proximity Read ↗

Oncogenic senescence: a multi-functional perspectiveSemantic proximity Read ↗

Cellular senescence in ageing: from mechanisms to therapeutic opportunities.Semantic proximity Read ↗

Impact of cellular senescence signature on ageing research.Semantic proximity Read ↗

Hallmarks and mechanisms of cellular senescence in aging and diseaseSemantic proximity Read ↗

Cellular Senescence in the Development and Treatment of CancerSemantic proximity Read ↗

Context-dependent effects of cellular senescence in cancer development.Semantic proximity Read ↗

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and agingSemantic proximity Read ↗

A guide to assessing cellular senescence in vitro and in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.