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Article

PPP1CA contributes to the senescence program induced by oncogenic Ras

4 Oct 2007

Abstract excerpt

Ectopic expression of conditional murine p53 (p53val135) and oncogenic ras is enough to induce a senescent-like growth arrest at the restrictive temperature. We took advantage of this cellular system to identify new key players in the ras/p53-induced senescence. Applying a retroviral-based genetic screen, we obtained an antisense RNA fragment against PPP1CA, the catalytic subunit of protein phosphatase 1alpha,...

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PMID: 18204081
DOI: 10.1093/carcin/bgm246

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