Article
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis.
Clinical science (London, England : 1979) - 14 Apr 2022
Hu Ning, Zhang Xiaoyi, Zhang Xuanzhe, Guan Yongjun, He Ruyuan, Xue Enfu, Zhang Xiaoyi, Deng Wenhong, Yu Jia, Wang Weixing, Shi Qiao
Abstract excerpt
Acute pancreatitis (AP) is an acute inflammatory disorder characterized by acinar cell death and inflammation. Multiple factors cause hyperglycemia after AP. Macrophage polarization is involved in tissue injury and repair, and is regulated by Notch signaling during certain inflammatory diseases. The present study explores the relationship among hyperglycemia, macrophage polarization, and Notch signaling during AP...
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