Article
Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
Gastroenterology - 1 Feb 2018
Sendler Matthias, Weiss Frank-Ulrich, Golchert Janine, Homuth Georg, van den Brandt Cindy, Mahajan Ujjwal M, Partecke Lars-Ivo, Döring Paula, Gukovsky Ilya, Gukovskaya Anna S, Wagh Preshit R, Lerch Markus M, Mayerle Julia
Abstract excerpt
BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response. We investigated how these processes interact during severe pancreatitis in mice. METHODS: Pancreatitis was induced in C57Bl/6 wild-type (control), cathepsin B (CTSB)-knockout, and cathepsin L-knockout mice by partial...
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