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Article

PRAME protein expression in DICER1-related tumours.

The journal of pathology. Clinical research - 1 May 2022

Thorner Paul S, Chong Anne-Sophie, Nadaf Javad, Benlimame Naciba, Marrano Paula, Chami Rose, Fu Lili, Foulkes William D

Abstract excerpt

DICER1 syndrome is an autosomal dominant tumour predisposition syndrome usually affecting persons under 30 years of age. Many of the associated benign and malignant lesions occur almost exclusively in DICER1 syndrome. One such tumour, pituitary blastoma (pitB), overexpresses PRAME 500x above control levels. PRAME (PReferentially expressed Antigen in MElanoma) is expressed in malignancies that are not...

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Identifiers

PMID: 35297207
DOI: 10.1002/cjp2.264
PMCID: PMC8977278

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