Article
DICER1 mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.
Pediatric blood & cancer - 1 Sept 2012
Doros Leslie, Yang Jiandong, Dehner Louis, Rossi Christopher T, Skiver Kerry, Jarzembowski Jason A, Messinger Yoav, Schultz Kris Ann, Williams Gretchen, André Nicolas, Hill D Ashley
Abstract excerpt
Embryonal rhabdomyosarcoma (ERMS) is the most common childhood sarcoma and is a component of the familial pleuropulmonary blastoma (PPB)-predisposition syndrome. Using the PPB model, we hypothesized that DICER1 mutations would be found in familial and sporadic forms of ERMS. Blood samples from four children with familial PPB and ERMS, and 52 sporadic ERMS tumors were tested for DICER1 mutations. Germline DICER1...
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