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Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

27 Aug 2010

Abstract excerpt

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of...

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PMID: 20799951
DOI: 10.1186/1476-4598-9-226

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