The Tumor-Associated Antigen <b> <i>PRAME</i> </b> Is Universally Expressed in High-Stage Neuroblastoma and Associated with Poor Outcome

Abstract excerpt

PURPOSE: The tumor-associated antigen PRAME, a potential candidate for immunotherapeutic targeting, is frequently expressed in a variety of cancers. However, no information about its presence in neuroblastoma is available to date. We therefore evaluated and quantified PRAME expression in a considerable number of neuroblastoma tumors and assessed its impact on the outcome of patients. EXPERIMENTAL DESIGN:...

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