Article
Molecular characterization of DICER1-mutated pituitary blastoma.
Acta neuropathologica - 1 Jun 2021
Nadaf Javad, de Kock Leanne, Chong Anne-Sophie, Korbonits Márta, Thorner Paul, Benlimame Naciba, Fu Lili, Peet Andrew, Warner Justin, Ploner Oswald, Shuangshoti Shanop, Albrecht Steffen, Hamel Nancy, Priest John R, Rivera Barbara, Ragoussis Jiannis, Foulkes William D
Abstract excerpt
Pituitary blastoma (PitB) has recently been identified as a rare and potentially lethal pediatric intracranial tumor. All cases that have been studied molecularly possess at least one DICER1 pathogenic variant. Here, we characterized nine pituitary samples, including three fresh frozen PitBs, three normal fetal pituitary glands and three normal postnatal pituitary glands using small-RNA-Seq, RNA-Seq, methylation...
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