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Article

Neuroectodermal elements are part of the morphological spectrum of DICER1-associated neoplasms.

Human pathology - 1 May 2022

McCluggage W Glenn, Stewart Colin J R, Belcijan Neza Lebic, Mourad Stephanie, Goudie Catherine, Chan Joshua C K, Liu Anthony, Alaggio Rita, Foulkes William D

Abstract excerpt

Many sarcomas with DICER1 pathogenic variants (PVs) exhibit a characteristic morphology, including a subepithelial layer of malignant mesenchymal cells, areas of rhabdomyoblastic differentiation and cartilaginous and/or osseous elements. We report 5 DICER1-associated neoplasms (1 moderately to poorly differentiated Sertoli Leydig cell tumour and 4 sarcomas) containing variable amounts of neuroectodermal elements....

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Identifiers

PMID: 35245609
DOI: 10.1016/j.humpath.2022.02.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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