Article
Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.
Journal of the National Cancer Institute - 3 Oct 2012
Kuhn Elisabetta, Wu Ren-Chin, Guan Bin, Wu Gang, Zhang Jinghui, Wang Yue, Song Lei, Yuan Xiguo, Wei Lei, Roden Richard B S, Kuo Kuan-Tin, Nakayama Kentaro, Clarke Blaise, Shaw Patricia, Olvera Narciso, Kurman Robert J, Levine Douglas A, Wang Tian-Li, Shih Ie-Ming
Abstract excerpt
BACKGROUND: Uterine cancer is the fourth most common malignancy in women, and uterine serous carcinoma is the most aggressive subtype. However, the molecular pathogenesis of uterine serous carcinoma is largely unknown. We analyzed the genomes of uterine serous carcinoma samples to better understand the molecular genetic characteristics of this cancer. METHODS: Whole-exome sequencing was performed on 10 uterine...
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