Article

Compartmentalized Mitochondrial Ferroptosis Converges with Optineurin-mediated Mitophagy to Impact Airway Epithelial Cell Phenotypes and Asthma Outcomes

2023-08-01

Abstract excerpt

<title>Abstract</title> <p>A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox biology adversely affects mitochondria through activation of a variety of cell death and survival pathways, yet the understanding of mitochondria and their dysfunction in human disease states is modest. Ferroptosis, an iron dependent, oxidative stress associated programmed cell death pathway, is...

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Literature Corpus work: 75b570e3-7acc-5dee-be1f-06ec9b43e78a
DOI: 10.21203/rs.3.rs-3161394/v1

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