HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING1 pathway

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax regulatory protein plays a critical role in HTLV-1 persistence and pathogenesis; however, the underlying mechanisms are poorly understood. Here we show that Tax dynamically regulates mitocho...

Topics

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• Amyotrophic Lateral Sclerosis
• Autophagy in Disease and Therapy
• Cancer-related molecular mechanisms research
• Herpesvirus Infections and Treatments
• Inflammasome and immune disorders
• interferon and immune responses
• Intracellular Signaling Peptides and Proteins
• Mosquito-borne diseases and control

Identifiers and source

Literature Corpus work

dd520e33-1698-5ff2-9d7a-a1dc3b26c8cc

DOI

10.1101/2025.03.15.643451