Article

The metabolic reprogramming of T cells controls airway remodeling in severe asthma

2026-03-22

Abstract excerpt

Mixed granulocytic asthma (MGA) is a severe Th2-low endotype, characterized by high Th17/neutrophilic burden and exacerbated airway remodeling. Both features confer resistance to inhaled corticosteroids, and typical asthma treatments. Thus, MGA is an enormous public health burden. Gaps in knowledge include how Th17 cells induce pathological tissue remodeling, and how Th17 differentiation occurs in response to alle...

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Literature Corpus work: 928bb759-f1ec-5f76-984f-66ef059574a8
DOI: 10.64898/2026.03.19.712985

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