Article
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes.
Nature communications - 10 Jul 2024
Yamada Kazuhiro, St Croix Claudette, Stolz Donna B, Tyurina Yulia Y, Tyurin Vladimir A, Bradley Laura R, Kapralov Alexander A, Deng Yanhan, Zhou Xiuxia, Wei Qi, Liao Bo, Fukuda Nobuhiko, Sullivan Mara, Trudeau John, Ray Anuradha, Kagan Valerian E, Zhao Jinming, Wenzel Sally E
Abstract excerpt
A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox biology can adversely affect mitochondria through induction of a variety of cell death and survival pathways, yet the understanding of mitochondria and their dysfunction in primary human cells and in specific disease states, including asthma, is modest. Ferroptosis is traditionally considered an iron dependent,...
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