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Article

ASXL1/EZH2 mutations promote clonal expansion of neoplastic HSC and impair erythropoiesis in PMF.

Leukemia - 1 Jan 2019

Triviai Ioanna, Zeschke Silke, Rentel Jan, Spanakis Marios, Scherer Theo, Gabdoulline Razif, Panagiota Victoria, Thol Felicitas, Heuser Michael, Stocking Carol, Kröger Nicolaus

Abstract excerpt

Primary myelofibrosis (PMF) is a hematopoietic stem cell (HSC) disease, characterized by aberrant differentiation of all myeloid lineages and profound disruption of the bone marrow niche. PMF samples carry several mutations, but their cell origin and hierarchy in regulating the different waves of clonal and aberrant myeloproliferation from the prime HSC compartment is poorly understood. Genotyping of >2000...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer of Zeste Homolog 2 Protein

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Source

Identifiers

PMID: 29907810
DOI: 10.1038/s41375-018-0159-0

Genes

ASXL1
CALR
JAK2

Variants

Provenance

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