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Article

Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

18 Jan 2021

Abstract excerpt

Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin accessibility landscapes, we delineate core transcription regulatory circuitries (CRCs) of limbal stem/progenitor cells (LSCs) and find that RUNX1 and SMAD3 are required for maintenance of corneal epithelial...

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PMID: 33462242
DOI: 10.1038/s41467-020-20713-z

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