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Identification of the regulatory circuit governing corneal epithelial fate determination and disease

19 Oct 2023

Abstract excerpt

The transparent corneal epithelium in the eye is maintained through the homeostasis regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on epidermal keratinocytes for renewal. Despite their cellular similarities, the precise cell fates of these two types of epithelial stem cells, which give rise to functionally distinct epithelia, remain unknown. We performed a multi-omics analysis of...

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PMID: 37856539
DOI: 10.1371/journal.pbio.3002336

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