Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

Abstract excerpt

Abstract Background Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models. Method To recapitulate human CRCs, we generated Villin‐Cre;Smad4F/F;Trp53F/F mice. We then compared the intestinal phenotype of Villin‐Cre;Smad4F/F;Trp53F/F mice (n = 40) with...

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