Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential cancer mutations in cultured human intestinal stem cells.

Nature - 7 May 2015

Drost Jarno, van Jaarsveld Richard H, Ponsioen Bas, Zimberlin Cheryl, van Boxtel Ruben, Buijs Arjan, Sachs Norman, Overmeer René M, Offerhaus G Johan, Begthel Harry, Korving Jeroen, van de Wetering Marc, Schwank Gerald, Logtenberg Meike, Cuppen Edwin, Snippert Hugo J, Medema Jan Paul, Kops Geert J P L, Clevers Hans

Abstract excerpt

Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, R-spondin, epidermal growth factor (EGF) and noggin over long time periods as epithelial organoids that remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Intestines

Share to Neoplasm Transplantation

Share to Organoids

Share to Smad4 Protein

Share to Stem Cell Niche

Source

Identifiers

PMID: 25924068
DOI: 10.1038/nature14415

Genes

APC
EGF
KRAS
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25924068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential cancer mutations in cultured human intestinal stem cells.PMID 25924068Read ↗

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.Semantic proximity Read ↗

Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids.Semantic proximity Read ↗

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerSemantic proximity Read ↗

Shortcuts to intestinal carcinogenesis by genetic engineering in organoidsSemantic proximity Read ↗

Therapeutic implications of colon cancer stem cellsSemantic proximity Read ↗

Colorectal cancer stem cells.Semantic proximity Read ↗

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.Semantic proximity Read ↗

TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon CancerSemantic proximity Read ↗

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Semantic proximity Read ↗

A genome editing approach to study cancer stem cells in human tumorsSemantic proximity Read ↗

Stem vs non-stem cell origin of colorectal cancer.Semantic proximity Read ↗

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon OrganoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.