Article
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Nature communications - 8 Oct 2014
Chanrion Maia, Kuperstein Inna, Barrière Cédric, El Marjou Fatima, Cohen David, Vignjevic Danijela, Stimmer Lev, Paul-Gilloteaux Perrine, Bièche Ivan, Tavares Silvina Dos Reis, Boccia Giuseppe-Fulvio, Cacheux Wulfran, Meseure Didier, Fre Silvia, Martignetti Loredana, Legoix-Né Patricia, Girard Elodie, Fetler Luc, Barillot Emmanuel, Louvard Daniel, Zinovyev Andreï, Robine Sylvie
Abstract excerpt
Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construction and analysis of this network map depicting molecular mechanisms of EMT regulation based on...
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