Article
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.
Nature - 1 Oct 2020
Kadosh Eliran, Snir-Alkalay Irit, Venkatachalam Avanthika, May Shahaf, Lasry Audrey, Elyada Ela, Zinger Adar, Shaham Maya, Vaalani Gitit, Mernberger Marco, Stiewe Thorsten, Pikarsky Eli, Oren Moshe, Ben-Neriah Yinon
Abstract excerpt
Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer1,2. Here we studied the effects of hotspot gain-of-function mutations in Trp53 (the gene that encodes p53 in mice) in mouse models of WNT-driven intestinal cancer caused by Csnk1a1 deletion3,4 or ApcMin mutation5. Cancer in these models is known to be...
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