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Article

Autophagy and senescence of rat retinal precursor cells under high glucose

4 Jan 2023

Abstract excerpt

Backgrounds Diabetic retinopathy (DR) is a common diabetic ocular disease characterized by retinal ganglion cell (RGC) changes. An abnormal environment, hyperglycemia, may progressively alter the structure and function of RGCs, which is a primary pathological feature of retinal neurodegeneration in DR. Accumulated studies confirmed autophagy and senescence play a vital role in DR; however, the underlying...

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PMID: 36686430
DOI: 10.3389/fendo.2022.1047642

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