Article
Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia.
Molecular neurobiology - 1 May 2022
Tan Zihu, Yang Guang, Qiu Jing, Yan Wenjing, Liu Yu, Ma Zhengling, Li Jia, Liu Jing, Shan Nan
Abstract excerpt
Cerebral hypoperfusion plays a pivotal role in the ictus and development of vascular dementia (VaD) with neuropsychiatric symptoms. To date, few pharmacological interventions for neuropsychiatric symptoms are available in the VaD patients with neuropsychiatric impairments. Here, our results demonstrated that the extent of demyelination was dramatically deteriorated and the thickness of myelin sheath was evidently...
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