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Article

Salidroside attenuates cognitive deficits induced by chronic cerebral hypoperfusion via modulating microglial phenotypic transformation in mice.

Journal of neuroimmunology - 15 Mar 2025

Ji Weiwei, Zhang Zengyu, Jin Tingyu, Meng Danyang, Zhou Xuyou, Hu Jin, Wang Yong

Abstract excerpt

BACKGROUND: Chronic cerebral hypoperfusion (CCH) is a significant contributor to vascular cognitive impairment (VCI), often linked to cortical and hippocampal damage. This study investigates the therapeutic potential of salidroside (SLDS) in mitigating CCH-induced brain injury by modulating microglial activation and inflammatory responses. METHODS: We established a CCH model in mice using the 0.16/0.18 mm...

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Identifiers

PMID: 39908941
DOI: 10.1016/j.jneuroim.2025.578544

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