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Article

Physical exercise modulates the astrocytes polarization, promotes myelin debris clearance and remyelination in chronic cerebral hypoperfusion rats.

Life sciences - 1 Aug 2021

Jiang Ting, Luo Jing, Pan Xiaona, Zheng Haiqing, Yang Huaichun, Zhang Liying, Hu Xiquan

Abstract excerpt

AIMS: White matter damage is the main pathological feature of chronic cerebral hypoperfusion (CCH) and glial activation is crucial in this process. Physical exercise has protective effects on CCH, but the mechanism is unclear. Therefore, this study focuses on investigating the influence of physical exercise on activated astrocytes polarization and its role in CCH. MAIN METHODS: Rats were given wheel running 48 h...

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Identifiers

PMID: 33894268
DOI: 10.1016/j.lfs.2021.119526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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