Article
Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions.
Mediators of inflammation - 1 Jan 2020
Du Yu, Song Yufei, Zhang Xiaojie, Luo Yan, Zou Wenying, Zhang Jiawei, Fu Jianliang
Abstract excerpt
Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenesis of CCH-induced WMLs remains unknown. Therefore, we performed bilateral common carotid artery...
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