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Article

A genomic enhancer signature associates with hepatocellular carcinoma prognosis

26 Feb 2023

Abstract excerpt

Background & Aims: Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the matched adjacent normal tissues to understand the aberrant epigenetic events associated with HCC. Methods: We identified tumour differential enhancers and the...

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PMID: 37168287
DOI: 10.1016/j.jhepr.2023.100715

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