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Article

Systematic decoding of functional enhancer connectomes and risk variants in human glioma.

Nature cell biology - 1 Oct 2025

Bi Jinfang, Mo Weipeng, Liu Man, Song Yingjie, Xiao Qian, Fan Sibo, Wang Wenbin, Shi Tengfei, Zheng Yaoqiang, Lian Jie, Liu Rong, Chen Bohan, Huang Xiaofeng, Li Peng, Zhao Zhongfang, Shi Jiandang, Zhang Lei, Su Guangsong, Zhang Nu, Lu Wange

Abstract excerpt

Genetic and epigenetic variations contribute to the progression of glioma, but the mechanisms underlying these effects, particularly for enhancer-associated genetic variations in non-coding regions, still remain unclear. Here we performed high-throughput CRISPR interference screening to identify pro-tumour enhancers in glioma cells. By integrating genome-wide H3K27ac HiChIP data, we identified the target genes of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40830415
DOI: 10.1038/s41556-025-01737-3
PMCID: PMC12527947

Genes

MEIS1
SOX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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