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Article

Integrated functional genomics-identified LYRM4 promotes fumarate accumulation and hepatocellular carcinoma progression.

Archives of biochemistry and biophysics - 1 Aug 2025

Xu Yuan, Yang Yanting, Yu Xinyuan, Han Linyu, Liu Shuqing, Zhang Nasha, Yang Ming

Abstract excerpt

Multiple risk factors for HCC have been identified, however, not all individuals exposed to these factors will develop HCC, suggesting that genetic predisposition also contributes to hepatocarcinogenesis. Despite the identification of numerous single-nucleotide polymorphisms (SNPs) in HCC risk loci and several protein-coding susceptibility genes through genome-wide association studies (GWAS), the potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40320061
DOI: 10.1016/j.abb.2025.110448

Genes

LYRM4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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