Article
Genetic Control of Alternative Splicing and its Distinct Role in Colorectal Cancer Mechanisms.
Gastroenterology - 1 Nov 2023
Zhang Ming, Chen Can, Lu Zequn, Cai Yimin, Li Yanmin, Zhang Fuwei, Liu Yizhuo, Chen Shuoni, Zhang Heng, Yang Shuhui, Gen Hui, Jiang Yuan, Ning Caibo, Huang Jinyu, Wang Wenzhuo, Fan Linyun, Zhang Yi, Jin Meng, Han Jinxin, Xiong Zhen, Cai Ming, Liu Jiuyang, Huang Chaoqun, Yang Xiaojun, Xu Bin, Li Heng, Li Bin, Zhu Xu, Wei Yongchang, Zhu Ying, Tian Jianbo, Miao Xiaoping
Abstract excerpt
BACKGROUND & AIMS: Dysregulation of alternative splicing is implicated in many human diseases, and understanding the genetic variation underlying transcript splicing is essential to dissect the molecular mechanisms of cancers. We aimed to provide a comprehensive functional dissection of splicing quantitative trait loci (sQTLs) in cancer and focus on elucidating its distinct role in colorectal cancer (CRC)...
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