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Article

Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.

Endocrine-related cancer - 22 Apr 2022

Amar Jacques, Brunel Jeremy, Cardot Bauters Catherine, Jacques Virginie, Delmas Clément, Odou Marie-Françoise, Savagner Frédérique

Abstract excerpt

The release of excessive amounts of catecholamine by pheochromocytoma-paragangliomas (PPGL) can lead to life-threatening catecholamine-induced cardiomyopathy (CIC). Single-nucleotide polymorphisms of the beta1 and alpha-2c adrenergic receptors alter myocyte receptor function and enhanced norepinephrine release. We tested the hypothesis that such genetic variations may impact the risk of developing CIC in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35258481
DOI: 10.1530/ERC-21-0373

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