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Article

The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy.

Journal of cardiac failure - 1 Sept 2007

Sarzani Riccardo, Forleo Cinzia, Pietrucci Francesca, Capestro Alessandro, Soura Elli, Guida Pietro, Sorrentino Sandro, Iacoviello Massimo, Romito Roberta, Dessì-Fulgheri Paolo, Pitzalis Mariavittoria, Rappelli Alessandro

Abstract excerpt

BACKGROUND: Idiopathic dilated cardiomyopathy (IDC) has multiple genetic and acquired causes. Apelin is an endogenous peptide that increases cardiac inotropism through his APJ receptor. No data are available concerning the APJ gene mutations responsible for IDC or on the role of APJ receptor gene variants in predicting heart failure (HF) progression. METHODS AND RESULTS: We prospectively evaluated 202 consecutive...

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PMID: 17826642
DOI: 10.1016/j.cardfail.2007.04.002

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