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Article

Apolipoprotein E in Alzheimer's disease: an update.

Annual review of neuroscience - 1 Jan 2014

Yu Jin-Tai, Tan Lan, Hardy John

Abstract excerpt

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD. Although the mechanisms that underlie the pathogenic nature of APOE in AD are still not completely understood, emerging data suggest that APOE...

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Identifiers

PMID: 24821312
DOI: 10.1146/annurev-neuro-071013-014300

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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