Article
Chronic Insulin Exposure Induces ER Stress and Lipid Body Accumulation in Mast Cells at the Expense of Their Secretory Degranulation Response.
PloS one - 1 Jan 2015
Greineisen William E, Maaetoft-Udsen Kristina, Speck Mark, Balajadia Januaria, Shimoda Lori M N, Sung Carl, Turner Helen
Abstract excerpt
Lipid bodies (LB) are reservoirs of precursors to inflammatory lipid mediators in immunocytes, including mast cells. LB numbers are dynamic, increasing dramatically under conditions of immunological challenge. We have previously shown in vitro that insulin-influenced lipogenic pathways induce LB biogenesis in mast cells, with their numbers attaining steatosis-like levels. Here, we demonstrate that in vivo...
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