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Article

Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients.

International journal of cancer - 1 Jun 2022

Starita Noemy, Pezzuto Francesca, Sarno Sabrina, Losito Nunzia Simona, Perdonà Sisto, Buonaguro Luigi, Buonaguro Franco M, Tornesello Maria Lina

Abstract excerpt

Penile carcinoma develops either through human papillomavirus (HPV) related or unrelated carcinogenic pathways. Genetic alterations and nucleotide changes in coding regions (ie, TP53, CDKN2A, PIK3CA and NOTCH1) are main cancer driver events either in HPV positive or in HPV negative tumours. We investigated the presence of hotspot nucleotide mutations in TERT promoter (TERTp) and PIK3CA exon 9 and their...

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Share to Carcinoma, Squamous Cell
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Identifiers

PMID: 35253909
DOI: 10.1002/ijc.33990
PMCID: PMC9310576

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