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Article

Highly prevalent<i>TERT</i>promoter mutations in bladder cancer and glioblastoma

15 May 2013

Abstract excerpt

Telomerase reverse transcriptase (TERT) activities are frequently upregulated in human cancers, which is thought to be an important mechanism contributing to human tumorigenesis.1,2 Mutations in the TERT promoter were recently reported in melanomas.3,4 Two of them, 1,295,228 C > T and 1,295,250 C > T (termed C228T and C250T, respectively), were particularly common. These mutations were found to be absent in...

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PMID: 23603989
DOI: 10.4161/cc.24662

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