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Article

TERT Promoter Mutations as Simple and Non-Invasive Urinary Biomarkers for the Detection of Urothelial Bladder Cancer in a High-Risk Region.

International journal of molecular sciences - 18 Nov 2022

Pakmanesh Hamid, Anvari Omid, Forey Nathalie, Weiderpass Elisabete, Malekpourafshar Reza, Iranpour Maryam, Shahesmaeili Armita, Ahmadi Nahid, Bazrafshan Azam, Zendehdel Kazem, Kannengiesser Caroline, Ba Ibrahima, McKay James, Zvereva Maria, Hosen Md Ismail, Sheikh Mahdi, Calvez-Kelm Florence Le

Abstract excerpt

Bladder cancer (BC) is the 10th most common cancer in the world. While there are FDA-approved urinary assays to detect BC, none have demonstrated sufficient sensitivity and specificity to be integrated into clinical practice. Telomerase Reverse Transcriptase (TERT) gene mutations have been identified as the most common BC mutations that could potentially be used as non-invasive urinary biomarkers to detect BC....

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Source

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Identifiers

PMID: 36430798
DOI: 10.3390/ijms232214319
PMCID: PMC9696845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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