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Article

Effect of co-occurring mutations in TP53 gene and TERT promoter on the survival of bladder cancer patients.

Frontiers in immunology - 1 Jan 2026

Tornesello Maria Lina, Piccirillo Maria Carmela, Tambaro Rosa, Simeon Vittorio

Abstract excerpt

Background: Mutations in the TP53 gene and telomerase reverse transcriptase promoter (TERTp) are among the most frequent genetic alterations in bladder cancer, but the clinical impact of their co-occurrence has not been fully explored. In this study, we assessed the mutational landscape as well as the prognostic significance of concurrent TERTp and TP53 mutations in a cohort of bladder urothelial carcinoma...

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Share to Biomarkers, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41878440
DOI: 10.3389/fimmu.2026.1771897
PMCID: PMC13006593

Genes

TP53
IMPACT
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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