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Article

Mutation and evolution of metallo-beta-lactamase CphA under the selective pressure of biapenem continuous concentration gradient.

Journal of inorganic biochemistry - 1 May 2022

Dong Xiaoting, Wang Jing, Wang Zhuanhong, Shi Penghui, Bian Liujiao

Abstract excerpt

One of the resistance mechanisms of superbugs is to hydrolyze antibiotics by producing metallo-β-lactamases (MβLs). To verify how MβLs evolved to increase in activity in response to various β-lactam antibiotics, the mutation and evolution of CphA from Aeromonas hydrophila (Zn2+-dependent MβL) was investigated in a medium with a continuous biapenem (BIA) concentration gradient. The results showed that a...

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PMID: 35247853
DOI: 10.1016/j.jinorgbio.2022.111776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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