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Article

A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.

Journal of molecular biology - 28 Jan 2005

Garau Gianpiero, Bebrone Carine, Anne Christine, Galleni Moreno, Frère Jean-Marie, Dideberg Otto

Abstract excerpt

One strategy developed by bacteria to resist the action of beta-lactam antibiotics is the expression of metallo-beta-lactamases. CphA from Aeromonas hydrophila is a member of a clinically important subclass of metallo-beta-lactamases that have only one zinc ion in their active site and for which no structure is available. The crystal structures of wild-type CphA and its N220G mutant show the structural features...

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Identifiers

PMID: 15588826
DOI: 10.1016/j.jmb.2004.10.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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