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Targeting Metallo-β-Lactamase Enzymes in Antibiotic Resistance

1 Jul 2013

Abstract excerpt

The β-lactam antibiotics are essential for the treatment of a wide range of human bacterial diseases. However, a class of zinc-dependent hydrolases known as the metallo-β-lactamase (MBL) can confer bacteria with extended spectrum β-lactam resistance. To date, there are no clinically approved MBL inhibitors, making these enzymes a serious threat to human health. In this review, a structural approach is taken to...

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Identifiers

PMID: 23859206
DOI: 10.4155/fmc.13.55

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