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A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

11 Sept 2017

Abstract excerpt

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design has been limited by the incomplete knowledge of their mechanism. Here, we report a biochemical and biophysical study...

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PMID: 28912448
DOI: 10.1038/s41467-017-00601-9

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