Article

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse and widespread in the environment

2019-08-16

Abstract excerpt

Antibiotic resistance has emerged as a major global health threat. The Zn 2+ -dependent metallo-β-lactamases (MBLs) are of particular concern as they act on the most widely prescribed class of antibiotics, the β-lactams, and are largely unaffected by commonly used β-lactamase antagonists such as clavulanic acid. MBLs are subdivided into three groups (B1 to B3); despite low overall sequence similarity, their catal...

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Literature Corpus work: ebfc6b2e-f6d7-5199-97aa-bd82c2a3b12e
DOI: 10.1101/737403

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