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Article

Crystal structure and kinetic analysis of the class B3 di-zinc metallo-β-lactamase LRA-12 from an Alaskan soil metagenome.

PloS one - 1 Jan 2017

Rodríguez María Margarita, Herman Raphaël, Ghiglione Barbara, Kerff Frédéric, D'Amico González Gabriela, Bouillenne Fabrice, Galleni Moreno, Handelsman Jo, Charlier Paulette, Gutkind Gabriel, Sauvage Eric, Power Pablo

Abstract excerpt

We analyzed the kinetic properties of the metagenomic class B3 β-lactamase LRA-12, and determined its crystallographic structure in order to compare it with prevalent metallo-β-lactamases (MBLs) associated with clinical pathogens. We showed that LRA-12 confers extended-spectrum resistance on E. coli when expressed from recombinant clones, and the MIC values for carbapenems were similar to those observed in...

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PMID: 28750094
DOI: 10.1371/journal.pone.0182043
PMCID: PMC5531557

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