Article
A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.
mBio - 19 Nov 2019
Cheng Zishuo, Shurina Ben A, Bethel Christopher R, Thomas Pei W, Marshall Steven H, Thomas Caitlyn A, Yang Kundi, Kimble Robert L, Montgomery Jonathan S, Orischak Matthew G, Miller Callie M, Tennenbaum Jordan L, Nix Jay C, Tierney David L, Fast Walter, Bonomo Robert A, Page Richard C, Crowder Michael W
Abstract excerpt
To understand the evolution of Verona integron-encoded metallo-β-lactamase (VIM) genes (blaVIM) and their clinical impact, microbiological, biochemical, and structural studies were conducted. Forty-five clinically derived VIM variants engineered in a uniform background and expressed in Escherichia coli afforded increased resistance toward all tested antibiotics; the variants belonging to the VIM-1-like and...
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