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Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors

19 Apr 2025

Abstract excerpt

Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics, which are our widest applied and cheapest to produce antibiotic agents. So far, no clinically applicable metallo-β-lactamase inhibitors are available. Aiming to adapt...

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PMID: 40253435
DOI: 10.1038/s42004-025-01510-5

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