Article

Functionality-Informed Fine-Mapping Dissects Common Variant Contributions to Coronary Artery Disease and Identifies Causal Variants and Pathways

2026-04-02

Abstract excerpt

<h4>Summary</h4> Genomics offer a powerful approach to identify causal mechanisms underlying coronary artery disease (CAD) risk, with implications for pathogenesis, personalized prevention strategies, and therapeutic target discovery. Functionality-informed genome-wide fine mapping was performed using the Bayesian framework SBayesRC to estimate genetic contributions of 6.9 million common variants, based on GWAS s...

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Literature Corpus work: 7ed36a36-b29b-5a56-ae07-c709ea2f7093
DOI: 10.64898/2026.04.01.26349823

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