A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.

doi:10.1016/j.exphem.2022.02.005

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Article

A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.

Experimental hematology - 1 May 2022

Kato Hisaya, Maezawa Yoshiro, Nishijima Dai, Iwamoto Eisuke, Takeda June, Kanamori Takashi, Yamaga Masaya, Mishina Tatsuzo, Takeda Yusuke, Izumi Shintaro, Hino Yutaro, Nishi Hiroyuki, Ishiko Jun, Takeuchi Masahiro, Kaneko Hiyori, Koshizaka Masaya, Mimura Naoya, Kuzuya Masafumi, Sakaida Emiko, Takemoto Minoru, Shiraishi Yuichi, Miyano Satoru, Ogawa Seishi, Iwama Atsushi, Sanada Masashi, Yokote Koutaro

Abstract excerpt

Werner syndrome (WS) is a progeroid syndrome caused by mutations in the WRN gene, which encodes the RecQ type DNA helicase for the unwinding of unusual DNA structures and is implicated in DNA replication, DNA repair, and telomere maintenance. patients with WS are prone to develop malignant neoplasms, including hematological malignancies. However, the pathogenesis of WS-associated hematological malignancies...

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PMID: 35240258
DOI: 10.1016/j.exphem.2022.02.005

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