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Article

Transcriptional neighborhoods regulate transcript isoform lengths and expression levels.

Science (New York, N.Y.) - 4 Mar 2022

Brooks Aaron N, Hughes Amanda L, Clauder-Münster Sandra, Mitchell Leslie A, Boeke Jef D, Steinmetz Lars M

Abstract excerpt

Sequence features of genes and their flanking regulatory regions are determinants of RNA transcript isoform expression and have been used as context-independent plug-and-play modules in synthetic biology. However, genetic context-including the adjacent transcriptional environment-also influences transcript isoform expression levels and boundaries. We used synthetic yeast strains with stochastically repositioned...

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PMID: 35239377
DOI: 10.1126/science.abg0162
PMCID: PMC7613581

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